29 June 2018
New optical tweezers system installed at the University of Oxford.
Ionovation teamed up with PicoQuant to develop and finalize an optical tweezers system with time-resolved confocal microscopy.
In a joint development, Ionovation combined their highly versatile optical tweezers system PicoTweezers with PicoQuant's MicroTime 200, the most flexible tool for time-resolved fluorescence microscopy. One of the first users is the University of Oxford. "This promising system allows us to monitor intracellular activity on a new level by contactless trapping and positioning various cell types. We can now scrutinize cell response in great detail and avoid any unwanted cell activation that otherwise would occur when cells get in mechanical contact with surfaces" said Christian Eggeling, Professor of Molecular Immunology in the MRC Human Immunology Unit and head of the Wolfson Imaging Centre at the Weatherall Institute of Molecular Medicine, University of Oxford. The instrument records fluorescence as exemplified by monitoring intracellular responses like calcium flashes. "This indicates for us the potential of PicoTweezers for cellular experiments, ranging from simultaneous fluorescence recordings to potential force measurements, such as cell-cell interactions.
26 April 2018
TwinTweezers – Optical tweezers to investigate biological interactions on a molecular level.
Ionovation GmbH and the Microbiological Department of Osnabrück University established a joint development of a novel dual trap optical tweezers system with video-based force detection which is funded by the development bank of the federal state of Lower Saxony - NBank.
The TwinTweezers system will allow to quantitatively measure molecular forces during interactions between two living cells and between cells and bacteria. Capable to individually trap, navigate and manipulate living biological specimens, this tweezers system gives deeper insights into several microbiological functions covering:
• Infection biology: the interaction of pathogenic bacteria (e.g: salmonella enterica) with epithelium cells
• Tumor biology: force measurements of cell migration in a 3D cell matrix
• Cell biology: controlling membrane compartments to investigate their transport in mammalian cells
• Immunology: interaction of dendritic cells and T-cells as well as the formation of immunological synapses as a result of adaptive immune response
To improve the microbiological measurements performed with the TwinTweezers system, a temperature controlled sample chamber and seamless integration of fluorescence excitation will be included into the instrument.
13 February 2018
Best of two worlds: combining optical tweezers with time-resolved confocal microscopy
PicoQuant and Ionovation now offer an integrated platform that combines microscopy and force spectroscopy
Berlin (Germany) – As a joint development, PicoQuant and Ionovation combined time-resolved microscopy and optical tweezers in a single system. Both instruments retain their individual functionalities but can also be used together , thus enabling customers to carry out time-resolved fluorescence microscopy (e.g., fluorescence lifetime imaging) on trapped objects such as cells.
PicoQuant and Ionovation will showcase the features of this combined system at the 62nd Biophysical Society Meeting in San Francisco (February 17- 21, 2018).
PicoQuant‘s MicroTime 200 platform is the most flexible and extensible high-end research tool for time-resolved fluorescence microscopy requiring single molecule sensitivity. The system is an excellent choice for many methods, including Pulsed Interleaved Excitation (PIE), Förster Resonance Transfer (FRET), Stimulated Emission Depletion (STED) super-resolution microscopy, Fluorescence (Lifetime) Correlation Spectroscopy (F(L)CS), and anisotropy measurements.
Ionovation’s PicoTweezers system is a compact, robust trapping and force measurement device based on the “optical tweezers” concept which is equipped with real-time video detection. In contrast to common optical tweezers systems, PicoTweezers has no spatial restrictions and is compatible to all sample carriers. The system is well suited for molecular interaction studies, force spectroscopy, cell trapping, rheology and many other applications.
PicoQuant is a leading research and development company specializing in optoelectronics, which was founded in 1996. The company, based in the science and technology park of Berlin-Adlershof, Germany, is a worldwide leader in the field of single photon counting applications. The product portfolio encompasses picosecond pulsed diode lasers and LEDs, photon counting instrumentation, fluorescence lifetime spectrometers, FLIM and FCS upgrade kits for laser scanning microscopes as well as time-resolved confocal and super-resolution microscopes. Since April 2008 Sales and Support in North America is handled by PicoQuant Photonics North America Inc. The PicoQuant group employs currently around 80 people.
Founded in 2004, Ionovation represents a wealth of experience in the development, integration and automation of complementary technical and scientific systems in the fields of life-sciences. Ionovation's unique combination of modern analytical methods with a broad range of microscopy techniques translates into a product line ranging from automated lipid bilayer (BLM) workstations to robust and easy to use optical tweezers for unprecedented force spectroscopy applications as well as industry compliant 3D-cell culture and Organ-on-Chip supply systems.
Dr. Karsten Gall
Tel.: +49 5402 968 979 30
February 17 - 21, 2018 | San Francisco
Just like every year since 2008 Ionovation will be presenting instruments and tools for biomembrane research and optical tweezers at the Biophysical Meeting.
If you find your way to one of the most exciting cities in the world visit us at booth #609 for a chat with our experts about your research and/or our instruments .
This years special:
The worlds most flexible optical tweezers system, "Ionovation PicoTweezers" will be presented in cooperation with PicoQuant (booth #418). The combination of the PicoTweezers with PicoQuant's MicroTime 200 and other high-end microscopes will be demonstrated. Meet the experts from PicoQuant and Ionovation and discuss your most challenging needs for your optical applications with us.
By the end of 2017 Ionovation has moved to a more spacious and fancy new location. Find us in the "Innovationsforum Bissendorf" near Osnabrück.
Our new address is:
Gewerbepark 9 - 11
+49 5402 968 979 30
+49 5402 968 979 39